Vaccine Mandate Threatens Major Trucking Disruption, Industry Insiders Say

American truckers don’t like taking orders. But the Biden administration has increased pressure on some of them to take the vaccine—willing or unwilling.

All through the pandemic, truckers endured hardships to keep America’s infrastructure running. They waited in line for hours in sight of bathrooms they weren’t allowed to use. On the road, some died alone of COVID-19.

Now, with supply chains disrupted, Americans need them more than ever. But faced with the prospect of mandated vaccination, many drivers are considering quitting.

“I’d fight it,” said veteran trucker Mike Widdins,...