Nearly a year and a half since Covid-19 was detected in the Chinese city of Wuhan, the question of how the virus first emerged remains a mystery.
But in recent weeks the controversial claim that the pandemic might have leaked from a Chinese laboratory - once dismissed by many as a fringe conspiracy theory - has been gaining traction.
Now, US President Joe Biden has announced an urgent investigation that will look into the theory as a possible origin of the disease.
So what do we know about the competing theories - and why does the debate matter?
It's a suspicion that the coronavirus may have escaped, accidentally or otherwise, from a laboratory in the central Chinese city of Wuhan where the virus was first recorded.
Its supporters point to the presence of a major biological research facility in the city. The Wuhan Institute of Virology (WIV) has been studying coronaviruses in bats for over a decade.
The laboratory is located just a few kilometres from the Huanan wet market where the first cluster of infections emerged in Wuhan.
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