Kayothera, Inc. Nominates KAYO-1732, a First-In-Class, Oral Inhibitor of the Retinoid Nuclear Receptor Pathway in Type 2 Diabetes and Cardiometabolic Indications as a Development Candidate

Kayothera, Inc. (“Kayothera”), a preclinical therapeutics company developing first-in-class, small molecule inhibitors of the retinoid nuclear receptor pathway, today announces that it has selected KAYO-1732 as a drug development candidate. KAYO-1732 is a novel, orally-available, small molecule inhibitor of the Aldehyde dehydrogenase 1A3 (ALDH1A3) enzyme, developed for the treatment of type 2 diabetes (T2D) and cardiovascular disorders. The compound has demonstrated an exceptional safety profile in 28-day toxicology studies and has shown dramatic disease-modifying activity in preclinical cardiometabolic models, supporting its potential as a transformative therapeutic. With the nomination of...