Speaking to a divided country in the midst of a pandemic, just weeks after the Capitol riot, he vowed to bring back unity and do "great things".
"We can right wrongs. We can put people to work in good jobs. We can teach our children in safe schools. We can overcome this deadly virus," he said.
A year into his presidency, we take a look at what progress Mr Biden has made, his standing with the American public, and what it all means for the president going forward, with analysis from the BBC's North America correspondent Anthony Zurcher.
Despite a bitter presidential race, Mr Biden began his term with 56% of the country approving of his performance, according to RealClearPolitics, and having won more than 80 million votes - more than any other president.
But in his first year, he has had a startling slide in fortunes.
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