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Fat molecule’s inability to bond with shape-shifting protein in cell’s powerhouse linked to an inherited metabolic disease

Posted on AllSides June 7th, 2024
From The Center

By studying mutations in yeast and human cells, Johns Hopkins Medicine scientists say they have found that biochemical bonds between fats and proteins in the mitochondrion, the cell’s powerhouse, play a crucial role in how our cells produce energy. The study results, published June 5 in The EMBO Journal, shed new light, researchers say, on the way the altered mitochondrial membranes found in people with metabolic diseases such as Barth syndrome, a rare genetic disorder that weakens the heart, fail to enable cellular power production. Metabolism is a set of...

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