Macron says France should make life miserable for the unvaccinated.

President Emmanuel Macron of France drew fierce criticism on Wednesday, mainly from his political opponents, after bluntly arguing that the government should make life miserable for the unvaccinated, as skyrocketing infection rates have put him under pressure ahead of a presidential election.

“I really want to piss off the unvaccinated,” Mr. Macron said in an interview with a panel of readers of Le Parisien, a newspaper. “And so we are going to continue doing that, until the end.”

Mr. Macron appeared to be trying to capitalize on frustration in France with...